Phosphocreatine
(byJoseph F. Clark, Ph.D.)
In the cell, PCr is not involved in any reactions other than with CK. PCr does however, have another use. It can bind to the cell's membranes and protect the cell by stabilizing the membranes. Intravenous PCr (2 g per day) has been given to athletes during strenuous endurance training. PCr allowed the athletes to train longer and they reported less muscle stiffness. The important drawback for PCr administration is that it must be given intramuscularly or intravenously, because it is readily broken down when taken orally. Most of these effects are attributed to the membrane protective action, but, when PCr is degraded it forms inorganic phosphate (Pi) and creatine. Therefore, PCr has the same benefits as oral creatine administration as well as the membrane effec
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