Immunohistochemistry Analysis Of Osteosarcoma In Patients With And Without Metastasis And Its Progno
(Abadi, Marcia Datz)
We study, by imunohistochemistry technique, the proteins p53, MDM-2,c-Kit, ErbB-2, PCNA and p-glycoprotein in samples of osteosarcomatumors at diagnosis and its correlation with the prognosis of thispatients. The p-53 was positive in 23,1% (9/39), PCNA in 71,4% (25/35),p-glycoprotein in 40,5% (15/37), MDM-2 in 34,8% (8/23), c-kit in67,8%(25/37) and ErbB-2 in 17,9% (7/39) of the samples. In theunivariate analysis, the presence of metastasis at diagnosis, thepositivity of p-53 and ErbB-2 influenced the prognosis individually,otherwise, in the multivariate analysis, the presence of metastasis atdiagnosis was the only prgnostic factor statistically significant.
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