Resumo de Treatment Of Aids And Hiv Infection

Anti-HIV (also called antiretroviral) medications are used to control the reproduction of the virus and to slow the progression of HIV-related disease. Highly Active Antiretroviral Therapy (HAART) is the recommended treatment for HIV infection. HAART combines three or more anti-HIV medications in a daily regimen, sometimes referred to as a ?cocktail?. Anti-HIV medications do not cure HIV infection and individuals taking these medications can still transmit HIV to others. Anti-HIV medications approved by the U.S. Food and Drug Administration (FDA) fall into four classes: 1. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs), such as Efavirenz (Sustiva), bind to and block the action of reverse transcriptase, a protein that HIV needs to reproduce. 2. Nucleoside Reverse Transcriptase Inhibitors (NRTIs), such as zidovudine (Retrovir), tenofovir DF (Viread), and stavudine (Zerit), are faulty versions of building blocks that HIV needs to make more copies of itself. When HIV uses an NRTI instead of a normal building block, reproduction of the virus is stalled. 3. Protease Inhibitors (PIs), such as lopinavir/ritonavir (Kaletra), disable protease, a protein that HIV needs reproduce itself. 4. Fusion Inhibitors, such as enfuvirtide (Fuzeon ), are newer treatments that work by blocking HIV entry into cells. (View more complete list of HIV drugs). How many pills you will need to take and how often you will take them depends on what medications you and your doctor choose. There is no one ?best? regimen. You and your doctor will decide which medications are right for you. For people taking HAART for the first time, the recommended regimens are: ? Sustiva + Epivir + (Retrovir or Viread or Zerit) ? Kaletra + Epivir + (Retrovir or Zerit) In general, taking only one or two drugs is not recommended because any decrease in viral load is almost always temporary without three or more drugs. The exception is the recommendation for pregnant women, who may take Retrovir alone or with other drugs to reduce the risk of passing HIV to their infants. If you are pregnant or considering becoming pregnant, there are additional treatment considerations. The treatment of HIV infection and AIDS is in a highly dynamic state. Individuals with this condition are advised to seek out experts in their local community who are current with the latest modes of therapy and ongoing clinical trials for evaluating newer therapies. The following is a partial list of drugs approved for the treatment of HIVinfection. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) Delavirdine (Rescriptor, DLV) Pfizer Efavirenz (Sustiva, EFV) Bristol-Myers Squibb Nevirapine (Viramune, NVP) Boehringer Ingelheim Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Abacavir (Ziagen, ABC) GlaxoSmithKline Abacavir,Lamivudine, Zidovudine (Trizivir) GlaxoSmithKline Didanosine (Videx, ddI, Videx EC) Bristol-Myers Squibb Emtricitabine (Emtriva, FTC, Coviracil) Gilead Sciences Lamivudine (Epivir, 3TC) GlaxoSmithKline Lamivudine, Zidovudine (Combivir) GlaxoSmithKline Stavudine ( Zerit, d4T) Bristol-Myers Squibb Tenofovir DF (Viread, TDF) Gilead Sciences Zalcitabine (Hivid, ddC) Hoffmann-La Roche Zidovudine (Retrovir, AZT, ZDV) GlaxoSmithKline Protease Inhibitors (PIs) Amprenavir (Agenerase, APV) GlaxoSmithKline, Vertex Pharmaceuticals Atazanavir (Reyataz, ATV) Bristol-Myers Squibb Fosamprenavir (Lexiva, FPV) GlaxoSmithKline, Vertex Pharmaceuticals Indinavir (Crixivan, IDV) Merck Lopinavir, Ritonavir (Kaletra, LPV/r) Abbott Laboratories Nelfinavir (Viracept, NFV) Agouron Pharmaceuticals Ritonavir (Norvir, RTV) Abbott Laboratories Saquinavir (Fortovase, SQV) Invirase Hoffmann-La Roche Fusion Inhibitors Enfuvirtide (Fuzeon, T-20) Hoffmann-La Roche, Trimeris

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